abstract：:Origin of drug and radio-refractory clones, cancer stem-like cells, and rapid angiogenesis and metastasis are among the primary concerns that limit the efficacy of anticancer treatments, emphasizing the urgency of developing new therapeutics. Factors like high attrition rates, huge investments, patients' heterogeneity...

journal_title：Life sciences

authors： Nath J,Paul R,Ghosh SK,Paul J,Singha B,Debnath N

更新日期：2020-10-01 00:00:00

abstract：AIMS:Coronavirus disease 2019 (COVID-19) has appeared in Wuhan, China but the fast transmission has led to its widespread prevalence in various countries, which has made it a global concern. Another concern is the lack of definitive treatment for this disease. The researchers tried different treatment options which are...

journal_title：Life sciences

authors： Hosseini FS,Amanlou M

更新日期：2020-10-01 00:00:00

abstract：AIMS:The study aimed to investigate whether IL-23 is amplified in monocyte subsets of MP pneumonia and to determine its relevant pathway. MATERIALS AND METHODS:We firstly analyze the IL-23p19 expression in monocyte subgroups in MP pneumonia patients and healthy controls subjects by using flow cytometry. Then, we also ...

journal_title：Life sciences

authors： Wang Z,Bao H,Liu Y,Wang Y,Qin J,Yang L

更新日期：2020-10-01 00:00:00

abstract：AIMS:Cancer Stem Cells (CSCs) refers to heterogeneous tumor cells retaining the abilities of self-renewal and differentiation. This study used mRNAsi, which is an index to describe the similarity between tumor cells and CSCs, to define genes involved in endometrial carcinoma. MATERIALS AND METHODS:The mRNA expression ...

journal_title：Life sciences

authors： Liu J,Wu Z,Sun R,Nie S,Meng H,Zhong Y,Nie X,Cheng W

更新日期：2020-10-01 00:00:00

abstract：:The risk of atherosclerosis (AS) ascends among post-menopausal women, while current hormone replacement therapy exerts several adverse effects. Alisol B 23-acetate (AB23A), a tetracyclic triterpenoid isolated from the rhizome of Alisma orientale, was reported to show multiple physiological activities, including regula...

journal_title：Life sciences

authors： Chen Q,Chao Y,Zhang W,Zhang Y,Bi Y,Fu Y,Cai D,Meng Q,Li Y,Bian H

更新日期：2020-10-01 00:00:00

abstract：AIMS:Studies on diabetes mellitus have shown that the phosphoinositide 3-kinase (PI3K)/serine threonine kinase (AKT)/forkhead box protein O1 (FoxO1) signaling pathway can regulate insulin secretion by modulating the expression of pancreatic and duodenal homeobox-1 (PDX-1). Therefore, it was hypothesized that the pathwa...

journal_title：Life sciences

authors： Zhang B,Sun P,Shen C,Liu X,Sun J,Li D,Liu Z,Zhang W,Zhang K,Niu Y

更新日期：2020-10-01 00:00:00

abstract：:Alzheimer's disease (AD) is the most common form of dementia worldwide. β-amyloid peptide (Aβ) is currently assumed to be the main cause of synaptic dysfunction and cognitive impairments in AD, but the molecular signaling pathways underlying its neurotoxic consequences have not yet been completely explored. Additional...

journal_title：Life sciences

authors： Amidfar M,de Oliveira J,Kucharska E,Budni J,Kim YK

更新日期：2020-09-15 00:00:00

abstract：AIM:Up-regulation of inflammasome proteins was reported in dystrophin-deficient muscles. However, it remains to be determined whether inflammasome activation plays a role in the pathogenesis of Duchenne muscular dystrophy. This study was therefore set out to investigate whether genetic disruption of the inflammasome pa...

journal_title：Life sciences

authors： Lau YS,Zhao L,Zhang C,Li H,Han R

更新日期：2020-09-15 00:00:00

abstract：:Despite the recent scientific advances made in cancer diagnostics and therapeutics, cancer still remains the second leading cause of death worldwide. Thus, there is a need to identify new potential biomarkers/molecular targets to improve the diagnosis and treatment of cancer patients. In this regard, long non-coding R...

journal_title：Life sciences

authors： Sharma U,Barwal TS,Malhotra A,Pant N,Vivek,Dey D,Gautam A,Tuli HS,Vasquez KM,Jain A

更新日期：2020-09-15 00:00:00

abstract：:Diabetes mellitus is one of the major global health issues, which is closely related to metabolic dysfunction and the chronic inflammatory diseases. Multiple studies have demonstrated that serum bilirubin is negatively correlated with metabolic syndrome and associated inflammatory diseases, including atherosclerosis, ...

journal_title：Life sciences

authors： Novák P,Jackson AO,Zhao GJ,Yin K

更新日期：2020-09-15 00:00:00

abstract：:Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is currently defined as the worst pandemic disease. SARS-CoV-2 infects human cells via the binding of its S protein to the receptor angiotensin-converting enzyme (ACE2). The use of ACEIs/ARBs (RAAS inhibitors) ...

journal_title：Life sciences

authors： Zhang J,Wang M,Ding W,Wan J

更新日期：2020-09-15 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Sepsis is a life-threatening organ dysfunction syndrome arising from uncontrolled inflammatory responses. Liver injury is a crucial factor for the prognosis of sepsis. Camptothecins (CPTs) have been reported to suppress the inflammatory response induced by sepsis. G2, a CPT-bile acid conjugate...

journal_title：Life sciences

authors： Xiao LX,Qi L,Zhang XL,Zhou YQ,Yue HL,Yu ED,Li QY

更新日期：2020-09-15 00:00:00

abstract：AIMS:Mild traumatic brain injury (mTBI) is an important risk factor for cognitive impairment. Despite intense efforts to develop efficient treatments, the current therapies are not often effective and far from satisfactory. Silymarin has been suggested as a therapeutic agent in the treatment of traumatic brain injury. ...

journal_title：Life sciences

authors： Shokouhi G,Kosari-Nasab M,Salari AA

更新日期：2020-09-15 00:00:00

abstract：:The COVID-19 pandemic raised by SARS-CoV-2 is a public health emergency. However, lack of antiviral drugs and vaccine against human coronaviruses demands a concerted approach to challenge the SARS-CoV-2 infection. Under limited resource and urgency, combinatorial computational approaches to identify the potential inhi...

journal_title：Life sciences

authors： Bharadwaj S,Lee KE,Dwivedi VD,Kang SG

更新日期：2020-09-15 00:00:00

abstract：:Sleep-disordered breathing is characterized by disruptions of normal breathing patterns during sleep. Obesity is closely related to hypoventilation or apnea and becomes a primary risk factor for sleep-disordered breathing. Leptin, a peptide secreted by adipose tissue, has been implicated in central control of breathin...

journal_title：Life sciences

authors： Wei Z,Hao Y,Yu H,Shi L,Jing X,Zhang X,Liu N,Li T,Zhang X,Yuan F

更新日期：2020-09-15 00:00:00

abstract：:Although renin-angiotensin system (RAS) imbalance is manifested in cardiomyopathies with different etiologies, the impact of RAS effectors on Chagas cardiomyopathy and skeletal myositis is poorly understood. Given that diminazene aceturate (DMZ) shares trypanocidal, angiotensin-converting enzyme 2 (ACE2) and angiotens...

journal_title：Life sciences

authors： Souza-Silva TG,Vilas-Boas DF,Gonçalves-Santos E,Mazzeti AL,Caldas IS,Gonçalves RV,Diniz LF,Novaes RD

更新日期：2020-09-15 00:00:00

abstract：BACKGROUND:Cardiovascular disease (CVD) is the leading cause of mortality worldwide. Cardiac fibrosis is the scarring process occurs commonly with CVDs impairing the function and structure of heart. Herein, we investigated the role of circPAN3 in the pathogenesis of cardiac fibrosis. METHODS:A rat myocardial infarctio...

journal_title：Life sciences

authors： Li F,Long TY,Bi SS,Sheikh SA,Zhang CL

更新日期：2020-09-15 00:00:00

abstract：AIM:Preparation of pegylated gold nanorods (PEG-AuNRs) that are capable of converting near infrared (NIR) light into heat. Evaluation of cancer therapeutic efficacy and long-term toxicity of the proposed photothermal therapy in comparison with other conventional modalities. MATERIALS AND METHODS:Prepared PEG-AuNRs wer...

journal_title：Life sciences

authors： Monem AS,Sayed FA,Rageh MM,Mohamed N

更新日期：2020-09-15 00:00:00

abstract：AIMS:The molecular pathogenesis of COVID-19 is similar to other coronavirus (CoV) infections viz. severe acute respiratory syndrome (SARS) in human. Due to scarcity of the suitable treatment strategy, the present study was undertaken to explore host protein(s) targeted by potent repurposed drug(s) in COVID-19. MATERIA...

journal_title：Life sciences

authors： Hazra S,Chaudhuri AG,Tiwary BK,Chakrabarti N

更新日期：2020-09-15 00:00:00

abstract：AIMS:Bisphenol (BP)-A exposure can impair glucose and lipid metabolism. However, it is unclear whether this endocrine disruptor (ED) modulates these processes in postmenopause, a period with organic changes that increase the risk for metabolic diseases. Herein, we evaluated the effects of BPA exposure on adiposity, glu...

journal_title：Life sciences

authors： Figueiredo LS,Oliveira KM,Freitas IN,Silva JA Jr,Silva JN,Favero-Santos BC,Bonfleur ML,Carneiro EM,Ribeiro RA

更新日期：2020-09-01 00:00:00

abstract：AIMS:The dysregulation of circular RNAs (circRNAs) has been implicated in the progression of diabetic retinopathy (DR). This study aims to explore the role and underlying mechanism of hsa_circ_0081108 (circCOL1A2) in DR. MATERIALS AND METHODS:circCOL1A2, vascular endothelial growth factor (VEGF) and miR-29b expression...

journal_title：Life sciences

authors： Zou J,Liu KC,Wang WP,Xu Y

更新日期：2020-09-01 00:00:00

abstract：:The new Coronavirus (SARS-CoV-2) is the cause of a serious infection in the respiratory tract called COVID-19. Structures of the main protease of SARS-CoV-2 (Mpro), responsible for the replication of the virus, have been solved and quickly made available, thus allowing the design of compounds that could interact with ...

journal_title：Life sciences

authors： Hage-Melim LIDS,Federico LB,de Oliveira NKS,Francisco VCC,Correia LC,de Lima HB,Gomes SQ,Barcelos MP,Francischini IAG,da Silva CHTP

更新日期：2020-09-01 00:00:00

abstract：AIMS:The aim of the present study was to evaluate the oral resveratrol effects associated with diet and physical training changes on anthropometric and biochemical parameters. MAIN METHODS:25 individuals aged from 30 to 60 years old; with Body Mass Index (BMI) ≥ 30 kg/m2 were included in the study. Following the prima...

journal_title：Life sciences

authors： Batista-Jorge GC,Barcala-Jorge AS,Silveira MF,Lelis DF,Andrade JMO,de Paula AMB,Guimarães ALS,Santos SHS

更新日期：2020-09-01 00:00:00

abstract：:This study analyzed the relationship between infection by human T-cell lymphotropic virus type 1 (HTLV-1) and changes in the pulmonary system. Cohort and case-control study models that analyzed a causal association between HTLV-1 and changes in the pulmonary system were considered. There were no restrictions on langua...

journal_title：Life sciences

authors： Normando VMF PhD,Dias ÁRN Me,da Silva ALSE Lic,da Silva Pinto D PhD,de Souza Santos MC PhD,Rodrigues CL Lic,de Oliveira EM PhD,de Souza Filho LEC Me,de Brito Vieira W Esp,Andriolo RB PhD,Sousa RCM PhD,Falcão LFM PhD,Quaresma JAS

更新日期：2020-09-01 00:00:00

abstract：:Hyperglycemia and oxidative stress are the primary stressors that elicit mitochondria specific cell stress in diabetes. Here we hypothesized that elevated level of ROS in high glucose (HG) environment, trigger mitochondrial stress by damaging mitochondrial DNA (mtDNA), altering inflammatory mediators, and neurodegener...

journal_title：Life sciences

authors： Pal S,Rao GN,Pal A

更新日期：2020-09-01 00:00:00

abstract：AIMS:The beneficial effects of cannabinoid type 2 receptor (CB2R) activation have been verified in various tissue repair processes. Our recent study revealed CB2R activation promotes myogenesis partly through Nrf2 signaling in a mouse skeletal muscle ischemia-reperfusion (IR) injury model. Other relevant mechanisms nee...

journal_title：Life sciences

authors： Jiang P,Wang L,Zhang M,Zhang M,Wang C,Zhao R,Guan D

更新日期：2020-09-01 00:00:00

abstract：:Bacterial infection can negatively affect different parts of the male genital tract and subsequently cause impaired spermatogenesis and male fertility. However, most of the previous studies have focused on the infected organs of the male genital tract and there are not many studies that investigated the direct effect ...

journal_title：Life sciences

authors： Oghbaei H,Rastgar Rezaei Y,Nikanfar S,Zarezadeh R,Sadegi M,Latifi Z,Nouri M,Fattahi A,Ahmadi Y,Bleisinger N

更新日期：2020-09-01 00:00:00

abstract：AIMS:Head and neck squamous cell carcinoma (HNSCC) is an highly aggressive tumor with heterogeneous prognosis. We here report that immune-related genes (IRGs) could effectively distinguish prognostically different HNSCC patients. MATERIALS AND METHODS:MRNA levels of 1333 IRGs that from ImmPort database in HNSCC sample...

journal_title：Life sciences

authors： Yang J,Xie K,Li C

更新日期：2020-09-01 00:00:00

abstract：AIMS:This study aims to explore the effect and underlying mechanism of zoledronic acid (ZA) on the incidence of thyroid cancer (TC) tumorigenesis. MATERIALS AND METHODS:Human mononuclear cells THP-1 were differentiated into M2-like tumor associated macrophages (TAMs) by incubation with PMA followed by additional incub...

journal_title：Life sciences

authors： Lv J,Chen FK,Liu C,Liu PJ,Feng ZP,Jia L,Yang ZX,Hou F,Deng ZY

更新日期：2020-09-01 00:00:00

abstract：:miRNAs are a group of non-coding RNAs that have regulatory functions in post-transcriptional gene expression. These molecules play a fundamental role in cellular processes, for instance cell proliferation, apoptosis, migration, and invasion. Scientific investigations have previously established that miRNAs can either ...

journal_title：Life sciences

authors： Khalili N,Nouri-Vaskeh M,Hasanpour Segherlou Z,Baghbanzadeh A,Halimi M,Rezaee H,Baradaran B

更新日期：2020-09-01 00:00:00

abstract：AIMS:The aim of this study was to investigate the molecular mechanism underlying preterm white matter injury (WMI) via the identification and functional analysis of differentially expressed long non-coding RNAs (lncRNAs) and mRNAs. MAIN METHODS:A neonatal rat model of preterm WMI was established by ligating the common...

journal_title：Life sciences

authors： Wang D,Ye X,Xie H,Liu Y,Xu Y,Wang Y,Zhou Y,Zhou N,Wang J

更新日期：2020-08-15 00:00:00

abstract：AIMS:Amiodarone (AMIO) is currently used in medical practice to reverse ventricular tachycardia. Here we determine the effects of AMIO in the electromechanical properties of isolated left ventricle myocyte (LVM) from mice and guinea pig and in a cellular model of Long QT Syndrome Type 3 (LQTS-3) using anemone neurotoxi...

journal_title：Life sciences

authors： Beserra SS,Santos-Miranda A,Sarmento JO,Miranda VM,Roman-Campos D

更新日期：2020-08-15 00:00:00

abstract：AIMS:To explore the role of chemokine CC motif ligand 2 (CCL2) in spatial memory and cognition impairment, and the underlying mechanisms focused on inflammatory, glutamate metabolistic and apoptotic- associated mRNA expression. MATERIALS AND METHODS:Stereotaxic surgery was performed here to establish a rat model by bi...

journal_title：Life sciences

authors： Chen J,Tan L,Liao Y,Long J,Zhou Y,Wei J,Zhou Y

更新日期：2020-08-15 00:00:00

abstract：:Excessive fibrosis and extracellular matrix deposition resulting from upregulation of target genes expression mediated by transforming growth factor-beta (TGF-β)/SMAD and hypoxia inducible factor-1 (HIF-1) signaling pathways are the main mechanisms that drive keloid formation. Sumoylation is a protein posttranslationa...

journal_title：Life sciences

authors： Lin X,Wang Y,Jiang Y,Xu M,Pang Q,Sun J,Yu Y,Shen Z,Lei R,Xu J

更新日期：2020-08-15 00:00:00

abstract：AIMS:Data suggest pharmacological treatment of depression with selective serotonin reuptake inhibitors (SSRI) may impair bone health. Our group has previously modeled compromised craniofacial healing after treatment with sertraline, a commonly prescribed SSRI, and hypothesized potential culprits: alterations in bone ce...

journal_title：Life sciences

authors： Durham E,Zhang Y,LaRue A,Bradshaw A,Cray J

更新日期：2020-08-15 00:00:00

abstract：:Icariin (ICA), a flavonol glycoside isolated from Epimedium, has been considered as a potential alternative therapy for ischemic stroke. However, the protective mechanisms of ICA on cerebral ischemia-reperfusion (I/R) are not fully illuminated yet. The effects of ICA on ER stress and inflammatory response which were i...

journal_title：Life sciences

authors： Mo ZT,Liao YL,Zheng J,Li WN

更新日期：2020-08-15 00:00:00

abstract：AIMS:Skeletal muscle diseases have become to be the most common complication in patients with type 2 diabetic mellitus (T2DM). However, the effective therapies against skeletal muscle diseases are not yet available. Sulforaphane (SFN) is an organic isothiocyanate found in cruciferous plants. Our aim was to explore whet...

journal_title：Life sciences

authors： Wang M,Pu D,Zhao Y,Chen J,Zhu S,Lu A,Liao Z,Sun Y,Xiao Q

更新日期：2020-08-15 00:00:00

abstract：:Long non-coding RNA (LncRNA) involved in types of physiological insults and diseases via regulating the responses of complex molecular, including cerebral ischemia-reperfusion (I/R) injury. LncRNA SNHG16 played a potential role in ketamine-induced neurotoxicity. In this study, we utilized an in vitro cell model of I/R...

journal_title：Life sciences

authors： Pan H,Zhao F,Yang Y,Chang N

更新日期：2020-08-01 00:00:00

abstract：AIMS:In this study, we used a cross-junction microfluidic device for preparation of alendronate-loaded chitosan nanoparticles with desired characteristics to introduce a suitable element for bone tissue engineering scaffolds. MAIN METHODS:By controlling the reaction condition in microfluidic device, six types of alend...

journal_title：Life sciences

authors： Moradikhah F,Doosti-Telgerd M,Shabani I,Soheili S,Dolatyar B,Seyedjafari E

更新日期：2020-08-01 00:00:00

abstract：AIMS:As of the 28th April 2020, the COVID-19 pandemic has infiltrated over 200 countries and affected over three million confirmed people. We review different biomarkers to evaluate if they are able to predict clinical outcomes and correlate with the severity of COVID-19 disease. METHODS:A systematic review of the lit...

journal_title：Life sciences

authors： Kermali M,Khalsa RK,Pillai K,Ismail Z,Harky A

更新日期：2020-08-01 00:00:00